L-670,596 is a potent and selective thromboxane/prostaglandin endoperoxide receptor antagonist.
ChEBI: 2-[6,8-difluoro-9-[(4-methylsulfonylphenyl)methyl]-1,2,3,4-tetrahydrocarbazol-1-yl]acetic acid is a member of carbazoles.
Potent and selective thromboxane A 2 /prostaglandin endoperoxide receptor antagonist (IC 50 = 5.5 nM). Inhibits U-44069-induced contractions of guinea pig trachea (pA 2 = 9.0) and human platelet aggregation in vitro (IC 50 = 6.5 nM). Also prevents thromboxane-mediated endothelial cell death. Orally active in vivo .
L-670596 (0.03mg/kg ; i.v.; single) inhibits arachidonic acid and U-44069 induced bronchoconstriction in the guinea pig[1].
L-670596 (2 mg/kg; i.v.; single) inhibits platelet aggregation to collagen in pigs[2].
| Animal Model: | Guinea pig (arachidonic acid and U-44069 induced bronchoconstriction model)[1]. |
| Dosage: | 0.03mg/kg |
| Administration: | Intravenous injection; single. |
| Result: | Inhibited arachidonic acid and U-44069 induced bronchoconstriction. |
![(-)-6-8-DIFLUORO-2,3,4,9-TETRAHYDRO-9-[[4-(METHYLSULFONYL)PHENYL]METHYL]-1H-CARBAZOLE-1-ACETIC ACID Structure](/CAS/GIF/121083-05-4.gif)
