RIP1 kinase inhibitor 4 (Example 3) is a BBB-penetrable RIP1 kinase inhibitor (EC50: <100 nM). RIP1 kinase inhibitor 4 can be used for the research of cell programming necrosis-related diseases[1]. RIP1 kinase inhibitor 4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
RIPK1: ≤ 1000 nM nM (EC50)
[1] Su, Yaning, et al. Preparation of pyrazole and triazole heterocycle derivative as RIP1 kinase inhibitor. Patent. WO2023040870.
