ChemicalBook Product Catalog Chemical Reagents Organic reagents Aromatics 3,5-DIMETHOXYBENZYL BROMIDE

3,5-DIMETHOXYBENZYL BROMIDE

Product Name3,5-DIMETHOXYBENZYL BROMIDE
CAS877-88-3
MFC9H11BrO2
MW231.09
EINECS
MOL File877-88-3.mol

Chemical Properties

Melting point	69-70 °C (lit.)
Boiling point	292.1±25.0 °C(Predicted)
Density	1.384±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	soluble in Methanol
form	Crystalline Powder
color	White to brown
InChI	InChI=1S/C9H11BrO2/c1-11-8-3-7(6-10)4-9(5-8)12-2/h3-5H,6H2,1-2H3
InChIKey	BTHIGJGJAPYFSJ-UHFFFAOYSA-N
SMILES	C1(CBr)=CC(OC)=CC(OC)=C1
CAS DataBase Reference	877-88-3(CAS DataBase Reference)

Safety Information

Hazard Codes	C
Risk Statements	34
Safety Statements	26-27-36/37/39-45
RIDADR	UN 3261 8/PG 2
WGK Germany	3
HazardClass	8
PackingGroup	II
HS Code	29093090
Storage Class	8A - Combustible corrosive hazardous materials
Hazard Classifications	Eye Dam. 1 Skin Corr. 1B

MSDS

Provider	Language
SigmaAldrich	English

Usage And Synthesis

Uses

3,5-Dimethoxybenzyl bromide may be used in various organic synthesis such as 3,4,3′,5′-tetramethoxystilbene; 3,5-dimethoxyphenylacetic acid; 1-(3,5-dimethoxyphenyl)-4-pentene etc., and 3,5-Dimethoxybenzyl bromide may be used as starting material in the multi-step synthesis of resveratroland 3,5-dimethoxyhomophthalic acid.

Chemical Properties

3,5-DIMETHOXYBENZYL BROMIDE is White Solid

Uses

3,5-DIMETHOXYBENZYL BROMIDE is used in dimethoxybenzene alkyl addition.

Uses

3,5-Dimethoxybenzyl bromide may be used in the synthesis of:

3,4,3′,5′-tetramethoxystilbene
3,5-dimethoxyphenylacetic acid
1-(3,5-dimethoxyphenyl)-4-pentene

It may be used as starting material in the multi-step synthesis of resveratrol and 3,5-dimethoxyhomophthalic acid.

General Description

3,5-Dimethoxybenzyl bromide is an aromatic bromide.

Synthesis

705-76-0

877-88-3

General procedure for the synthesis of 3,5-dimethoxybenzyl bromide from 3,5-dimethoxybenzyl alcohol: 3,5-dimethoxybenzyl alcohol (1 mmol) was dissolved in anhydrous benzene (15 mL) under anhydrous conditions and phosphorus tribromide (0.5 mL) was added. The reaction mixture was stirred at room temperature until the reaction was complete. The target product 3,5-dimethoxybenzyl bromide was obtained in quantitative yield by conventional post-treatment.

References

[1] Journal of Steroid Biochemistry and Molecular Biology, 2013, vol. 137, p. 332 - 344
[2] Journal of Asian Natural Products Research, 2011, vol. 13, # 4, p. 290 - 296
[3] Patent: WO2016/164703, 2016, A1. Location in patent: Page/Page column 41
[4] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 24, p. 7683 - 7687
[5] Medicinal Chemistry Research, 2016, vol. 25, # 4, p. 627 - 643

3,5-DIMETHOXYBENZYL BROMIDE

Chemical Properties

Safety Information

MSDS

Usage And Synthesis

Preparation Products And Raw materials

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