M199 is a novel inhibitor of TLR3/9 activation, inducing secretion of IL-6, IL-8 and TNFalpha in human PBMCs.
Uses
M199 is a potent TLR3/TLR9 signaling inhibitor. M199 induces secretion of IL-6, IL-8 and TNFα in human PBMCs. M199 is used as a selective inducer of the immune response[1].
IC 50
TLR3; TLR9; IL-6; IL-8
References
[1] Natalija Kneevi Teofilovi, et al. 1-ethyl-3-(6-methylphenanthridine-8-il) urea modulates TLR3/9 activation and induces selective pro-inflammatory cytokine expression in vitro. Bioorg Med Chem Lett. 2017 Apr 1;27(7):1530-1537. DOI:10.1016/j.bmcl.2017.02.048
