1H-Benzimidazol-5-ol

4887-80-3

41292-65-3

General procedure for the synthesis of 1H-benzimidazol-5-ol from 5-methoxybenzimidazole: 5-methoxybenzimidazole (500 mg, 3.374 mmol) was dissolved in 48% hydrobromic acid (10 mL) and the reaction was carried out at reflux for 2 hours. After completion of the reaction, the mixture was cooled to room temperature and the solvent was removed by rotary evaporator under reduced pressure. The residue was azeotropically treated with toluene (50 mL) to give the final title compound 1H-benzimidazol-5-ol as a brown solid (701 mg, 96% yield).