lemnalol

Lemnalol is a natural marine compound isolated from the Formosan soft coral Lemnalia cervicorni. Lemnalol produced anti-inflammatory and analgesic effects in carrageenan-injected rats.

Lemnalol is a potent agent for neuropathic pain. Lemnalol possesses potent anti-inflammatory, analgesic and anti-tumor activities. Lemnalol has the capacity to attenuate hyperalgesia and allodynia by modulation of neuroinflammatory processes in neuropathy. Lemnalol modulates LPS-induced alterations of left atrial (LA) calcium homeostasis and blocks the NF-κB pathways, which may contribute to the attenuation of lipopolysaccharide (LPS)-induced arrhythmogenesis and neuropathic pain. Lemnalolis a ylangene-type sesquiterpenoid compound, isolated from Lemnalia cervicorni[1][2].

[1] Tai BY, et al. Lemnalol Modulates the Electrophysiological Characteristics and Calcium Homeostasis of Atrial Myocytes. Mar Drugs. 2019 Oct 30;17(11):619. DOI:10.3390/md17110619
[2] Lin YC, et al. Intrathecal lemnalol, a natural marine compound obtained from Formosan soft coral, attenuates nociceptive responses and the activity of spinal glial cells in neuropathic rats. Behav Pharmacol. 2011 Dec;22(8):739-50. DOI:10.1097/FBP.0b013e32834d0ecb