KT 362

KT-362 is a calcium channel antagonist, potassium channel antagonist and sodium channel antagonist. KT-362 is a new antiarrhythmic agent with vasodilating action on intracellular calcium mobilization of atrial muscle.

KT-362 is an intracellular calcium antagonist. KT-362 can inhibit NE-induced contractions and IP accumulation in vivo experiments[1].

[1] H Eskinder, et al. Effect of KT-362, a putative intracellular calcium antagonist, on norepinephrine-induced contractions and inositol monophosphate accumulation in canine femoral artery. J Cardiovasc Pharmacol. 1989, 13, 3. DOI:10.1097/00005344-198903000-00020