mycotrienin II

Ansatrienin b (82189-04-6) represents a novel class of ansamycins.1 Inhibits osteoclastic bone resorption.2 Potentiates the activity of several clinically useful antitumor agents.3 Translation inhibitor which prevents ICAM-1 expression induced by pro-inflammatory cytokines.4

Ansatrienin B, also known as Mycotrienin II and Antibiotic T 23II, was isolated from a Streptomyces sp.. Closely related to the cytotrienins and trienomycins, it displays potent activity against tumour cell lines and inhibits osteoclastic bone resorption. Ansatrienin B also significantly potentiates the action of several clinical anti-cancer agents.

[1] M SUGITA. Studies on mycotrienin antibiotics, a novel class of ansamycins. II. Structure elucidation and biosynthesis of mycotrienins I and II.[J]. Journal of Antibiotics, 1982, 35 11: 1467-1473. DOI:10.7164/antibiotics.35.1467
[2] D FEUERBACH. Mycotrienins. A new class of potent inhibitors of osteoclastic bone resorption.[J]. The Journal of Biological Chemistry, 1995, 270 43: 25949-25955. DOI:10.1074/jbc.270.43.25949
[3] YURIKO YAMADA. Mycotrienin II, a translation inhibitor that prevents ICAM-1 expression induced by pro-inflammatory cytokines[J]. Journal of Antibiotics, 2011, 64 5: 361-366. DOI:10.1038/ja.2011.23