AQ 148 is a potent competitive inhibitor of HIV-1 PR.
Uses
AQ148 is a HIV-1 protease inhibitor (Ki=137 nM). The IC50 values of AQ148 for the inhibition of HIV-1, HIV-2 and SIV aspartic proteases are 1.5 μM, 3.4 μM and 5 μM, respectively[1].
References
[1] Rutenber, et al. "A new class of HIV-1 protease inhibitor: the crystallographic structure, inhibition and chemical synthesis of an aminimide peptide isostere." Bioorganic & medicinal chemistry 4.9 (1996): 1545-1558. DOI:10.1016/0968-0896(96)00147-2
