Spilanthol ( 1-1.875 mg/kg, Ip, Once) shows antinociceptive activity in acetic acid-induced abdominal writhes Male ICR mice model and capsaicin-induced licking paw Male ICR mice model[2].
Spilanthol (30 mg/kg, Po, Once a day for four days) a protective effect against the intestinal damage associated in swiss mice model of intestinal mucositis induced by 5-fluorouracil (HY-90006)[4].
Spilanthol (800 mg/kg, Po, Once) has a diuretic effect in adult C57BL/6J male mice[5].
| Animal Model: | Acetic acid-induced abdominal writhes Male ICR mice model[2] |
| Dosage: | 1-1.875 mg/kg |
| Administration: | Intraperitoneal administration(i.p.), Once |
| Result: | As the dose increased, the number of abdominal contractions and licking behavior decreased, and a maximum antinociceptive effect of 46.67% |
| Animal Model: | Swiss mice model of intestinal mucositis induced by 5-fluorouracil[4]. |
| Dosage: | 30 mg/kg |
| Administration: | Oral adminstraion(p.o.), Once a day for four days |
| Result: | Showed the intestinal wall recovery, villi are higher and less irregularity and high number and greater length of intestinal crypts. |
| Animal Model: | Adult C57BL/6J male mice[5]. |
| Dosage: | 800 mg/Kg |
| Administration: | Oral adminstraion (p.o.), Once |
| Result: | Increased in urine output, sodium, and increased excretion of sodium, potassium and chloride. |
