Cyclopropanecarboxamide, N-[6-[3-[[[(2-methylpropyl)sulfonyl]amino]methyl]phenyl]-1H-indazol-3-yl]-

CDK-IN-14 (Compound 9) is a potent and selective CDKL2 (Cyclin-dependent kinase-like 2) inhibitor with an IC50 value of 460 nM. CDKL2 is involved in various biological processes such as tumorigenesis, development, and viral infections. CDK-IN-14 serves as a powerful tool for studying the biological functions of CDKL2 and holds promise for research in fields related to cancer, infections, and other diseases[1].

[1] Bashore F M, et al. Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2[J]. bioRxiv, 2024. DOI:10.1101/2024.05.12.593776