AZD2906 (5, 25, 50 mg/kg, p.o.) increases micronucleated immature erythrocytes (MIE) in the bone marrow of rats after treatment for 2 days[1].
AZD2906 (5, 25 mg/kg, p.o.) induces an accumulation of glycogen in the liver of rats, and exhibits cortical lymphocytic atrophy of a moderate to marked degree in the thymus of rats[1].
| Animal Model: | Male Wistar Han rats (10 weeks old)[1] |
| Dosage: | 5, 25, 50 mg/kg |
| Administration: | P.O. for 2 days |
| Result: | Caused significant increase in micronucleated immature erythrocytes (MIE) at all doses after analysis of the standard 2000 IE. |
