BET-IN-2 is a BET inhibitor with an IC50 of 52 nM for BRD4-BD1.
IC 50
BRD4 BD1: 52 nM (IC50)
References
[1] Hu J, et al. Discovery of a series of dihydroquinoxalin-2(1H)-ones as selective BET inhibitors from a dual PLK1-BRD4 inhibitor. Eur J Med Chem. 2017 Sep 8;137:176-195. DOI:10.1016/j.ejmech.2017.05.049
