BNS-22 is a DNA topoisomerase II (TOP2) catalytic inhibitor with the IC50 values of 2.8 μM and 0.42 μM for human TOP2α and TOP2β, respectively. BNS-22 induces abnormal division and has anti-proliferative activity[1].
BNS-22 is a derivative of natural product GUT-70 isolated from the stem bark of Calophyllum brasiliense exhibits antiproliferative activity against human cancer cells. It appears th at BNS-22 is a specific DNA-topoisomerase II (TOPO2) catalytic inhibitor. BNS-22 does not induce DNA damage.
topoisomerase II alpha: 2.8 μM (IC50, in human); topoisomerase II beta: 0.42 μM (IC50, in human)
[1] Makoto Kawatani, et al. Identification of a small-molecule inhibitor of DNA topoisomerase II by proteomic profiling. Chem Biol. 2011 Jun 24;18(6):743-51. DOI:
10.1016/j.chembiol.2011.03.012
