N-(Azido-PEG3)-N-bis(PEG4-acid)

N-(Azido-PEG3)-N-bis(PEG4-acid) is an aqueous soluble PEG linker that contains azide and carboxylic acid moieties. The azide group can undergo Click Chemistry reactions with alkynes. The carboxylic acid groups can is reactive with amine entity.

N-(Azido-PEG3)-N-bis(PEG4-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Azido-PEG3)-N-bis(PEG4-acid) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

PEGs

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005