TH34

Product NameTH34
CAS2196203-96-8
MFC15H16N2O2
MW256.3
EINECS
MOL File2196203-96-8.mol

Chemical Properties

Density	1.236±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	DMSO : 150 mg/mL (585.25 mM)
pka	9.04±0.10(Predicted)
form	Solid
color	White to off-white

Usage And Synthesis

Uses

TH34, an HDAC6/8/10 inhibitor with IC50s of 4.6 μM, 1.9 μM, and 7.7 μM respectively, shows high selectivity over HDAC1/2/3[1].

Biological Activity

TH34 is an HDAC6/8/10 inhibitor with IC50 values of 4.6 μM, 1.9 μM and 7.7 μM, respectively, showing high selectivity compared with HDAC1/2/3.

in vitro

TH34 induces caspase-dependent programmed cell death and cell cycle arrest in neuroblastoma cells.

target

HDAC6

4.6 μM (IC ₅₀ )

HDAC8

1.9 μM (IC ₅₀ )

HDAC10

7.7 μM (IC ₅₀ )

IC 50

HDAC6: 4.6 μM (IC₅₀); HDAC8: 1.9 μM (IC₅₀); HDAC10: 7.7 μM (IC₅₀)

References

[1] Kolbinger FR, et al. The HDAC6/8/10 inhibitor TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines. Arch Toxicol. 2018 Aug;92(8):2649-2664. DOI:10.1007/s00204-018-2234-8