LEUKOTOXIN

(±)9(10)-EpOME is the 9,10-cis epoxide of linoleic acid, generated by neutrophils during the oxidative burst.1 It has been recovered from the lungs of hyperoxic rats and from humans with acute respiratory distress syndrome.2 Mitochondrial dysfunction is the main feature of (±)9(10)-EpOME cytotoxicity, which may be due to the diol metabolites as well as the parent epoxide.3,4WARNING This product is not for human or veterinary use.

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[2] TAKAYUKI OZAWA . Biosynthesis of leukotoxin, 9, 10-epoxy-12 octadecenoate, by leukocytes in lung lavages of rat after exposure to hyperoxia[J]. Biochemical and biophysical research communications, 1986, 134 3: Pages 1071-1078. DOI: 10.1016/0006-291x(86)90360-8
[3] Kazuhiko Osaka. Leukotoxin, a linoleate epoxide : its implication in the late death of patients with extensive burns[C]. 1900: 0. DOI: 10.11501/3102376
[4] JEFFERY H. MORAN . Cytotoxicity of Linoleic Acid Diols to Renal Proximal Tubular Cells[J]. Toxicology and applied pharmacology, 1997, 146 1: Pages 53-59. DOI: 10.1006/taap.1997.8197
[5] ZONGYUAN WU, FANG WEI*    Analytical Strategy for Oxylipin Annotation by Combining Chemical Derivatization-Based Retention Index Algorithm and Feature Tandem Mass Spectrometric Fragmentation as a Biomarker Discovery Tool[J]. Analytical Chemistry, 2023, 95 43: 15933-15942. DOI: 10.1021/acs.analchem.3c02789
[6] JAMIE L LAHVIC. Specific oxylipins enhance vertebrate hematopoiesis via the receptor GPR132.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 37: 9252-9257. DOI: 10.1073/pnas.1806077115