CDK8/19-IN-2

Chemical Properties

Boiling point	597.8±60.0 °C(predicted)
Density	1.89±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka	8.50±0.10(predicted)

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Animal Model:	Female BALB/c nude mice (6-8 weeks, human AML cell line MV4-11 were inoculated subcutaneously at the right flanks of animals)^[1]
Dosage:	3 mg/kg, 10 mg/kg
Administration:	orally by gavage, once per day
Result:	Resulted in a dose-dependent inhibition of tumor growth, reaching end point tumor growth inhibition (TGI) of 29%, and 76% at 3 and 10 mg/kg, respectively, without affecting body weight.