Pomalidomide 5'-fluoro-6'-piperazine-4-methylpiperidine hydrochloride

Pomalidomide 5'-fluoro-6'-piperazine-4-methylpiperidine hydrochloride (ZJT1) is an E3 ubiquitin ligase cereblon based on Pomalidomide (HY-10984) (CRBN) ligand for recruitment of cereblon protein. Pomalidomide 5'-fluoro-6'-piperazine-4-methylpiperidine hydrochloride can be linked to protein ligand by linker to form PROTAC[1].

Cereblon

[1] Meng YL, et al. Novel polycyclic compound, composition and application thereof. CN115894450A. 2023-04-04.