The general procedure for the synthesis of 1-(2,2,2-trifluoroethyl)piperazine dihydrochloride from 1-Boc-4-(2,2,2-trifluoroethyl)piperazine was as follows: tert-butyl 4-(2,2,2-trifluoroethyl)piperazine-1-carboxylate (253 mg, 0.94 mmol) was dissolved in a dioxane solution (4.72 mL, 0.94 mmol) of methylene chloride (9 mL) and 4M hydrochloric acid. 18.9 mmol). The reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, the mixture was concentrated under vacuum and co-evaporated three times with dichloromethane to afford 1-(2,2,2-trifluoroethyl)piperazine dihydrochloride (200 mg, 0.977 mmol, 100% yield) as a beige solid.
