RINT1 (RAD50 interactor 1) is mainly involved in the regulation of telomere lengthening via Rb/E2F pathway. In control of telomere length, it forms a complex with p130 (a nucleolar phosphoprotein) and Rad50, which restricts telomerase-independent telomere lengthening in normal cells. The conserved central and C-terminal domains of RINT1 directly interact with Rad50 during late S and G2/M phases of cell cycle. It has been suggested th at RINT1 may be involved in the DNA damage repair via regulating cell cycle progression.
