AF 698 is a peripheral vasodilator. AF 698 may have a protective effect against the lethalality of hypobaric hypoxia.
AF 698 is a phthalate derivative of Apovincamine (HY-135743) that can be used as a peripheral vasodilator with selective vasomotor effects on cerebral microvascular circulation. AF 698 has better vasodilator effect than Vincamine (HY-B1021), but there is no significant difference in the protective effect of the two drugs against hypobaric hypoxia-induced lethality in mice[1].
[1] Marzo, et al. A new phthalidyl derivative of apovincaminic acid:(3 alpha, 16 alpha)-eburnamenine-14 carboxylic acid phthalidyl ester (AF 698). A preliminary report on its chemical and pharmacological properties. Arzneimittel-forschung 32.6 (1982): 601-603. PMID:7202363
