Unoprostane is a protectant against retinal degeneration in S334ter rhodopsin mutant rats. Neuroprotective agent.
ChEBI: Unoprostone is an oxo monocarboxylic acid, a prostaglandins Falpha and a ketone. It has a role as an antiglaucoma drug and an antihypertensive agent.
Unoprostone (Rescula) is supplied as a 0.15% sterileophthalmic solution. Unoprostone is somewhat unusual inthat it is a docosanoid (22-carbon atom) PGF2α analog marketedas the isopropyl ester. The natural 15-position alcoholis oxidized to the ketone as would be expected to occur invivo. Cautions and side effects are similar to those givenpreviously.
Unoprostone (0.06%, 0.12%; topical instillation; 3 μl) reduces mouse intraocular pressure (IOP) in a dose-dependent manner[3].
| Animal Model: | Male mice (6 weeks old)[3] |
| Dosage: | 0.06%, 0.12% |
| Administration: | Topical instillation; 3 μl |
| Result: | Reduced mouse IOP in a dose-dependent manner.
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