ACTH (1-17)

Product NameACTH (1-17)
CAS7266-47-9
MFC95H145N29O23S
MW2093.41
EINECS
MOL File7266-47-9.mol

Chemical Properties

Density	1.48±0.1 g/cm3(Predicted)
RTECS	GM7907000
storage temp.	−20°C
form	Lyophilized powder
Water Solubility	Soluble in Water
Sequence	Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg
InChIKey	MXNMAFWEFLFAJN-QBQLSIIBSA-N

Safety Information

WGK Germany	3
Storage Class	11 - Combustible Solids

MSDS

Provider	Language
SigmaAldrich	English

Usage And Synthesis

Uses

ACTH (1-17), an adrenocorticotropin analogue, is a potent human melanocortin 1 (MC1) receptor agonist with a Ki of 0.21 nM.

Biochem/physiol Actions

ACTH fragment with moderate adrenocorticotropic and melanocyte-stimulating activities.

in vivo

Inhibition of DNA labeling is noted when the ACTH (1-17) is administered at 2 hr after the beginning of the daily dark span when nocturnal animals become active. When administered at this circadian stage, the larger dose in particular is associated with an inhibition of DNA labeling lasting for 24 hr. The inhibitory effect is much shorter when the same dose is injected 4 hr earlier^[3].

References

[1] Tsatmali M et al. ACTH1-17 is a more potent agonist at the human MC1 receptor than alpha-MSH. Cell Mol Biol (Noisy-le-grand). 1999 Nov;45(7):1029-34. PMID:10644006
[2] Ceda GP, et al. The effects of ACTH (1-17) on GH secretion in vitro. Horm Metab Res. 1987 Aug;19(8):361-3. DOI:10.1055/s-2007-1011824
[3] Walker WV, et al. Effect of an adrenocorticotropin analogue, ACTH (1-17), on DNA synthesis in murine metaphyseal bone. Biochem Pharmacol. 1985 Apr 15;34(8):1191-6. DOI:10.1016/0006-2952(85)90494-0