ChemicalBook Product Catalog Biochemical Engineering Biochemical Reagents Agonist Inhibitors BAY-1082439

BAY-1082439

Chemical Properties

Density	1.43±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 5 mg/mL (10.11 mM; ultrasonic and adjust pH to 5 with HCl)
form	A solid
pka	10.27±0.20(Predicted)
color	White to off-white

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Animal Model:	Pten conditional knockout mouse model (Pb-Cre⁺;Pten^L/L, CP model)^[2]
Dosage:	75 mg/kg
Administration:	P.o.; daily for 4 weeks
Result:	Significantly decreased tumor size and P-AKT staining, nearly normal luminal architecture, and a significant reduction of Ki67-positive cells. Significantly inhibit the human prostate cancer growth.