6-Bromoindole-3-carboxylic acid

79878-02-7

101774-27-0

General procedure for the synthesis of 6-bromo-1H-indole-3-carboxylic acid from 1-(6-bromo-1H-indol-3-yl)-2,2,2-trifluoroethanone: 1-(6-bromo-1H-indol-3-yl)-2,2,2-trifluoroethanone (1.0 eq., 1.0 g) was mixed with a 20% aqueous sodium hydroxide solution (17 mL) and heated to 100 °C. Stirring was continued at this temperature until the reaction was complete (about 18 hours). After completion of the reaction, the solution was cooled to room temperature and washed twice with dichloromethane. Subsequently, the aqueous solution was acidified with hydrochloric acid to the appropriate pH, the precipitate precipitated was collected by filtration and dried under vacuum to afford the target product 6-bromo-1H-indole-3-carboxylic acid (715 mg, 87% yield).