273727-89-2
273727-89-2 性质
| 沸点 | 478.8±28.0 °C(Predicted) |
|---|---|
| 密度 | 1.083±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 7.99±0.50(Predicted) |
273727-89-2 用途与合成方法
|
JAK3 7.1 (pIC 50 ) |
JAK1 4.4 (pIC 50 ) |
EGF-R 5.6 (pIC 50 ) |
Lck 5.0 (pIC 50 ) |
CDK4 5.0 (pIC 50 ) |
TGM2 10 nM (IC 50 ) |
ZM39923 is a JAK3 inhibitor, with a pIC 50 of 7.1. ZM39923 (Compound 7) shows weak inhibitory effect on EGF-R and JAK1 (pIC 50 , 5.6, 4.4, respectively), and insignificantly inhibits tyrosine kinases Lck and CDK4 (pIC 50 <5.0). ZM39923 potently inhibits tissue transglutaminase (TGM2) with an IC 50 of 10 nM, and acts directly on purified TGM2 to inhibit the Ca 2+ activated form of TGM2. ZM39923 blocks the phosphorylation of JAK3 induced by CCL19, and such an effect is similar to that of CCR7 antibody. ZM39923 also significantly blocks the CCL19 induced wound closure rate, and decreases the migration and invasion of PCI-37B cells.
