S24–14 is a potent antiosteoporosis agent. S24–14 inhibits osteoclastogenesis with an IC50 value of 0.40 μM. S24–14 induces osteoblast differentiation. S24–14 suppresses bone loss[1].
References
[1] Huang D, et al. Discovery of Novel Antiosteoporosis Leads with Bone Resorption Inhibition and Anabolic Promotion through a Chemotype-Assembly Approach. J Med Chem. 2024 Sep 12;67(17):15311-15327. DOI:10.1021/acs.jmedchem.4c00909
