TCO-PEG8-NHS ester

TCO-PEG8-NHS Ester is a click chemistry PEG crosslinker with a TCO moiety and a NHS ester. The hydrophilic PEG spacer increases water-solubility and decreases steric hindrance during ligation. This reagent can be used to label antibodies, proteins and other primary amine-containing macromolecules with TCO moiety.

TCO-PEG8-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

PEGs

[1] Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10(2):207-238. DOI:10.1016/j.apsb.2019.08.001