Phenylacetyl-Coenzyme A (sodium salt)

Phenylacetyl-coenzyme A (CoA) is a key intermediate in aerobic catabolism of phenylacetate in bacteria such as Pseudomonas, when cultured in minimal media using phenylacetate as the sole carbon source.1 It is a precursor in the synthesis of the antibiotic penicillin G (Item No. 21615) found in industrial strains of P. chrysogenum. Phenylacetyl-CoA also acts as an effector molecule of the TetR family transcriptional repressor PaaR in T. thermophilus and the GntR family transcriptional regulator PaaX in E. coli and Pseudomonas, binding to each protein to induce derepression of various genes.2WARNING This product is not for human or veterinary use.

[1] B MIÑAMBRES. Molecular cloning and expression in different microbes of the DNA encoding Pseudomonas putida U phenylacetyl-CoA ligase. Use of this gene to improve the rate of benzylpenicillin biosynthesis in Penicillium chrysogenum.[J]. The Journal of Biological Chemistry, 1996, 271 52: 33531-33538. DOI: 10.1074/jbc.271.52.33531
[2] KEIKO SAKAMOTO. Phenylacetyl coenzyme A is an effector molecule of the TetR family transcriptional repressor PaaR from Thermus thermophilus HB8.[J]. Journal of Bacteriology, 2011, 193 17: 4388-4395. DOI: 10.1128/jb.05203-11