KRAS inhibitor-31

KRAS inhibitor-31 (compound 33) is a KRAS inhibitor, with KD (SPR) values of 0.019 nM, 0.019 nM and 0.096 nM for KRas G12D, KRas G12C and KRas G12V, respectively[1].

KRas G12D: 0.019 nM (Kd); KRas G12C: 0.019 nM (Kd); KRas G12V: 0.096 nM (Kd)

[1] Jacob Cole DEFOREST, et al. Pyrido[4,3-d]pyrimidine compounds. Patent WO2024009191.