Antiviral agent 58 CAS#: 939655-35-3

Uses

Antiviral agent 58 (Compound J1) is an orally active antiviral agent with broad-spectrum antiviral activity against enveloped viruses, including influenza A virus (IAV), respiratory syncytial virus (RSV), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), human coronavirus OC43 (HCoV-OC43), herpes simplex virus type 1 (HSV-1), and HSV-2[1].

in vivo

Antiviral agent 58 (Compound J1) (15-60 mg/kg; P.O.; Once daily for 5 days) can significantly reduce IAV-induced lung injury in BALB/c mice^[1].

Animal Model:	IAV lung injury BALB/c mouse model^[1].
Dosage:	15 mg/kg; 30 mg/kg; 60 mg/kg
Administration:	Oral, once daily for 5 days
Result:	Increased the survival rate of virus-infected mice, and decreased viral titer, lung index and lung inflammation damage.

References

[1] Li Y, et al. A small molecule compound targeting hemagglutinin inhibits influenza A virus and exhibits broad-spectrum antiviral activity[J]. Acta Pharmacologica Sinica, 2024: 1-14. DOI:10.1038/s41401-024-01331-7

Antiviral agent 58

Usage And Synthesis

Antiviral agent 58 Supplier