UK-9040, a derivative of the antihistamine Triprolidine (HY-B1808), is an orally active inhibitor of gastric secretory. UK-9040 reduces gastric acid, pepsin, and volume output in response to
food, Insulin (HY-P0035), Histamine (HY-B1204), N-methyl histamine, and Pentagastrin (HY-A0261)[1].
References
[1] D B Hamer, et al. Morphological and pharmacological studies of the parietal cells of the stomach in the dog during periods of maximal acid output and after the gastric secretory inhibitor UK-9040. Gut. 1977 Feb;18(2):91-8. DOI:10.1136/gut.18.2.91
![1-[(Z)-4-[5-(2,2-Dimethylpropyl)-2-thienyl]-4-phenyl-3-butenyl]pyrrolidine Structure](/CAS/GIF/47453-14-5.gif)
