(3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyldihydrofuran-2(3H)-one can be used for synthetic preparation for asymmetric synthesis of dibenzoyl fluoro methyl-D-ribono-γ-lactone via asymmetric aldol condensation and enzymic hydrolysis from isopropylidene-D-glyceraldehyde and Et fluoropropionate.
Chlorination or acylation of trans-5-hydroxy-1,3-oxathiolane-2-carboxylic acid-L menthol ester and coupling with cytosine and 5-fluorocytosine or with silicone-protected cytosine and 5-fluorocytosine. -The process of chlorination or acylation requires high requirements for the maintenance of the chiral structure, prolongs the process flow, increases the process cost, and reduces the yield of the final product.
