Aramchol is a fatty acid conjugate that exhibitshypocholesterolemic effects. Studies have shown that aramcholsuppresses the activity ofstearoyl-CoA desaturase (SCD), which leads to reduction of obesity, fatty liver and insulin resistance.
Arachidyl amido cholanoic acid (Aramchol) is a cholesterol solubilizer th at has the potential to prevent and dissolves cholesterol gallstones in inbred mice and in human gallbladder bile ex vivo.', 'Aramchol is a bile salt fatty acid conjugate (BAFAC) of arachidic acid and cholic acid. It has been shown to reduce liver f at by a dual mechanism of action. It inhibits the activity of liver stearoyl coenzyme A desaturase 1 (SCD1), decreasing the synthesis of fatty acids. In addition, it activates cholesterol efflux by stimulating the adenosine triphosphate–binding cassette transporter A1 (ABCA1). Aramchol has been investigated for treatment for nonalcoholic steatohepatitis, or NASH.
