2,6-Dichlorobenzonitrile NEW

• DATA ITEMS CITED :

• 17

• MOLECULAR FORMULA :

• C7-H3-Cl2-N

• MOLECULAR WEIGHT :

• 172.01

• WISWESSER LINE NOTATION :

• NCR BG FG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 2710 mg/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• REFERENCE :

• RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 10,97,1965

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Unreported

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 500 mg/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• REFERENCE :

• 30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971 Volume(issue)/page/year: -,145,1971

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 2056 mg/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• REFERENCE :

• 28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969 Volume(issue)/page/year: 5,73,1976

• TYPE OF TEST :

• LD - Lethal dose

• ROUTE OF EXPOSURE :

• Administration onto the skin

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• >200 mg/kg

• TOXIC EFFECTS :

• Sense Organs and Special Senses (Olfaction) - deviated nasal septum Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Biochemical - Metabolism (Intermediary) - lipids including transport

• REFERENCE :

• NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979- Volume(issue)/page/year: 15,287,1994

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Intraperitoneal

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 360 mg/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• REFERENCE :

• FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 41,41,1986

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rabbit

• DOSE/DURATION :

• 270 mg/kg

• TOXIC EFFECTS :

• Behavioral - somnolence (general depressed activity) Liver - other changes

• REFERENCE :

• FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 6,261,1968

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Administration onto the skin

• SPECIES OBSERVED :

• Rodent - rabbit

• DOSE/DURATION :

• 1350 mg/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• REFERENCE :

• GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada) Volume(issue)/page/year: 6,177,1973

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - guinea pig

• DOSE/DURATION :

• 681 mg/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• REFERENCE :

• PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS) Volume(issue)/page/year: -,337,1966

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Unreported

• SPECIES OBSERVED :

• Mammal - species unspecified

• DOSE/DURATION :

• 1 gm/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• REFERENCE :

• 30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971 Volume(issue)/page/year: -,144,1971 ** OTHER MULTIPLE DOSE TOXICITY DATA **

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Administration onto the skin

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 1 gm/kg/5D-I

• TOXIC EFFECTS :

• Sense Organs and Special Senses (Olfaction) - deviated nasal septum Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Biochemical - Metabolism (Intermediary) - lipids including transport

• REFERENCE :

• NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979- Volume(issue)/page/year: 15,287,1994 ** TUMORIGENIC DATA **

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Intraperitoneal

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 260 ug/kg/39D-I

• TOXIC EFFECTS :

• Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

• REFERENCE :

• AAATAP Annali dell'Accademia di Agricoltura di Torino. (Accademia de Agricoltura di Torino, Via Andrea Doria 10, 10123 Turin, Italy) 1870- Volume(issue)/page/year: 122,107,1979

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Subcutaneous

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 260 ug/kg/39D-I

• TOXIC EFFECTS :

• Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Tumorigenic - tumors at site of application

• REFERENCE :

• AAATAP Annali dell'Accademia di Agricoltura di Torino. (Accademia de Agricoltura di Torino, Via Andrea Doria 10, 10123 Turin, Italy) 1870- Volume(issue)/page/year: 122,107,1979 *** REVIEWS *** TOXICOLOGY REVIEW DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970. Volume(issue)/page/year: 80,485,1973 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 24030 No. of Facilities: 40 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 200 (estimated)