| Name | β-Amyloid (25-35) |
| Description | β-Amyloid (25-35) is a fragment of the Alzheimer’s amyloid beta peptide Aβ(25-35), exhibiting neurotoxic effects and commonly used to establish both cellular and animal models of Alzheimer’s disease. |
| In vitro | The amino acid sequence of β-Amyloid (25-35) is NH2-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-COOH, where the first Gly represents the amino acid 25 and the last Met represents the amino acid 35 and it is also investigated in gel state for the first time. Amyloid beta-peptide(25-35) induces apoptotic effects on isolated brain mitochondria and the redox state of methionine-35, plays a key role in the induction of programmed cellular death pathways and toxic events[2]. Comparative studies are also carried out using vibrational absorption and ECD. The conformational preference of Aβ(25-35) peptide film is also investigated using vibrational absorption and VCD spectroscopy[1]. |
| In vivo | The Alzheimer' s disease (AD) model group present with spatial learning and memory impairments. CDS and donepezil administration significantly ameliorate the Aβ25–35 peptide-induced memory impairment in both Morris water maze (P<0.05) and passive avoidance task (P<0.01) compared to the AD model group[3]. Rats are injected with β-Amyloid (25-35) intracerebroventricularly and compound Danshen (CDS) are subsequently administered once daily for 23 days. Rats' behavior is monitored using Morris water maze and passive avoidance. Real time PCR and Western blotting are used in determining amyloid precursor protein (APP), β-site APP cleaved enzyme-1(BACE1), Presenilin-1 (PS1), Insulin-degrading enzyme (IDE) and neprilysin (NEP) in hippocampus. |
| Storage | Powder: -20°C for 3 years
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 3.33 mg/mL (3.14 mM), Sonication is recommended.
DMSO : 97 mg/mL (91.49 mM), Sonication is recommended.
10% DMSO+90% Corn Oil : 3.3 mg/mL (3.11 mM), Sonication is recommended.
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| Keywords | β-amyloid peptide | βAmyloid (2535) | β-Amyloid | βAmyloid | β Amyloid (25 35) | β Amyloid | Inhibitor | inhibit | beta-Amyloid peptide | beta-Amyloid | BetaAmyloid | Beta Amyloid | b-Amyloid peptide | b-Amyloid | bAmyloid | b Amyloid | Amyloid-β | Amyloid β-peptide | Amyloid b-peptide | Amyloid beta-peptide | Abeta25-35 | Abeta | Ab25-35 |
| Inhibitors Related | Benzenesulfonamide | Deferoxamine Mesylate | Cromolyn sodium | HEPPS | Phytic acid sodium salt | Rutin | Resveratrol | 10-Undecenoic acid | 2,4-Di-tert-butylphenol | Chlorzoxazone | Methyl tridecanoate | Glimepiride |
| Related Compound Libraries | Peptide Compound Library |
United States
