| Name | (-)-Epigallocatechin Gallate |
| Description | (-)-Epigallocatechin Gallate (EGCG) is a phenolic antioxidant polyphenol flavonoid found in plants such as green and black tea, which inhibits telomerase and DNA methyltransferase, blocks the activation of EGF receptors and HER-2 receptors, inhibits cellular oxidation, and prevents free radical damage to cells. |
| Cell Research | LoVo, SW480, HCT-8, and HT-29 cells are seeded in 96-well plates at a concentration of 5×103?cells; each cell line is totally seeded in the 12 wells. Complete medium is added to the wells, up to 200 μL; the medium contains 0 μg/mL, 10 μg/mL, 20 μg/mL, and 35 μg/mL of epigallocatechol gallate. The inhibition rate=[1 - (absorbance of Epigallocatechol Gallate group - absorbance of control group)/(absorbance of control group - absorbance of blank control group)] × 100. |
| In vitro | METHODS: Human thyroid cancer cells TT, TPC-1 and ARO were treated with (-)-Epigallocatechin Gallate (10-200 µM) for 24 h. Cell viability was detected using MTS assay. |
| In vivo | METHODS: To investigate the protective effect against acute injury, (-)-Epigallocatechin Gallate (200 mg/kg) was administered to ICR mice by gavage once a day for one week, followed by intraperitoneal injection of LPS (15 mg/kg) to induce acute injury.
RESULTS: (-)-Epigallocatechin Gallate protects mice from LPS-induced acute stress, while stabilizing gut microorganisms, improving sphingolipid metabolism, and inhibiting harmful metabolite levels. [3] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 242.5 mg/mL (529.05 mM), Sonication is recommended.
H2O : 50 mg/mL (109.08 mM), Sonication is recommended.
Ethanol : 45.8 mg/mL (99.92 mM), Sonication is recommended.
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| Keywords | Thyroid cancer | ReactiveOxygenSpecies | Reactive Oxygen Species | MitochondrialMetabolism | Mitochondrial Metabolism | LPS-induced bone resorption | Inhibitor | inhibit | HIVProtease | HIV Protease | HIV | Ferroptosis | FB-2 cells | Epigallocatechin Gallate | EndogenousMetabolite | Endogenous Metabolite | colorectal cancer | cell proliferation. | Autophagy | ()Epigallocatechin Gallate | ( ) Epigallocatechin Gallate |
| Inhibitors Related | Sucrose | Aceglutamide | Hemin | Nicotinamide riboside malate | DL-Lysine | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Malic acid | Glycerol | Thymidine | Corn starch | Gluconate Calcium |
| Related Compound Libraries | Bioactive Compound Library | Natural Product Library | Drug Repurposing Compound Library | Miao medicine Compound Library | Inhibitor Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-virus Traditional Chinese Medicine Monomer Library | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | Ancient Chinese Classical Formulas Compound Library | Anti-Cancer Active Compound Library | Anti-Cancer Drug Library |
United States
