| Name | α-Lipoic Acid sodium |
| Description | α-Lipoic Acid sodium (Thioctic acid sodium) is an antioxidant and essential cofactor for mitochondrial enzyme complexes. It inhibits NF-κB-dependent HIV-1 replication, induces endoplasmic reticulum stress-mediated apoptosis in hepatocellular carcinoma cells, and modulates SREBP-1, FOXO1, and Nrf2 to improve high-fat diet-induced hepatic steatosis. |
| In vitro | α-Lipoic Acid sodium (250, 500, and 1000 μM) significantly increased the NAD⁺/NADH ratio in HepG2 cells; α-Lipoic Acid (50, 125, 250, and 500 μM) enhanced SIRT1 activity in HepG2 cells; α-Lipoic Acid (50, 125, 250, 500, and 100 μM) promoted the phosphorylation levels of AMPK and ACC in HepG2 cells in a dose-dependent manner [1]. |
| In vivo | α-Lipoic Acid sodium (100 mg/kg or 200 mg/kg) significantly reduces visceral fat content in mice on a long-term high-fat diet, while also suppressing appetite and causing a notable decrease in body weight [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 28 mg/mL (122.64 mM), Sonication is recommended.
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| Keywords | α-Lipoic Acid sodium | Thioctic acid sodium ; (±)-α-Lipoic acid sodium ; DL-α-Lipoic acid sodium | DL-alpha-Lipoic acid sodium | DL-a-Lipoic acid sodium | alpha-Lipoic Acid sodium | a-Lipoic Acid sodium |
| Inhibitors Related | Stavudine | Aceglutamide | Emtricitabine | Urea | Tamoxifen | Cysteamine hydrochloride | Lamivudine | Metronidazole | Ethyl linoleate | Formamide | Alginic acid | Sildenafil citrate |
| Related Compound Libraries | NF-κB Signaling Compound Library | Bioactive Compound Library | Anti-Viral Compound Library | Lipid Metabolism Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Transcription Factor-Targeted Compound Library |
United States
