1. Materials information
Names
| Name | s-allyl-l-cysteine |
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| Synonym | More Synonyms |
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S-Allyl-L-cysteine Biological Activity
| Description | S-Allyl-L-cysteine, one of the organosulfur compounds found in AGE, possess various biological effects including neurotrophic activity, anti-cancer activity, anti-inflammatory activity. |
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| Related Catalog | Signaling Pathways >> Others >> Others Research Areas >> Cancer Research Areas >> Neurological Disease Natural Products >> Others Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease Research Areas >> Others |
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| In Vitro | It is found that S-Allyl-L-cysteine could protect against amyloid-protein (A)-and tunicamycin-induced cell death in differentiated PC12 cells. Simultaneously applied S-Allyl-L-cysteine (1 μM) suppresses the cell death induced by Aβ25-35 and Aβ1-40 in a concentration-dependent manner, and neuronal integrity is almost completely retained. Simultaneously applied S-Allyl-L-cysteine significantly decreases the Aβ-induced level of ROS. The TEAC value of S-Allyl-L-cysteine is lower than that of oxidized GSH, and no antioxidant activity is observed. Intracellular GSH levels remains unaffected by treatment of neurons with S-Allyl-L-cysteine for 24 h. Furthermore, the increase in caspase-12 protein expression is suppressed by simultaneously adding 1 μM S-Allyl-L-cysteine [1]. S-Allyl-L-cysteine up to a concentration 1.0 mM does not exhibit any cytotoxic impact on morphology of myoblast and myotubes in culture observed under bright field microscope. TNF treatment leads to a significant decrease in the intracellular CK activity while S-Allyl-L-cysteine pre-treatment to TNF treated myotubes decreases the release of CK in media. S-Allyl-L-cysteine pre-treatment decreases the level of active form of this enzyme in S-Allyl-L-cysteine+TNF group. Similar observations are recorded at mRNA level for caspase-3. These results illustrate that S-Allyl-L-cysteine regulates apoptotic signals via suppressing the transcription and thus protein expression of caspase-3[2]. |
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| References | [1]. Kosuge Y, et al. S-allyl-L-cysteine selectively protects cultured rat hippocampal neurons from amyloid beta-protein- and tunicamycin-induced neuronal death. Neuroscience. 2003;122(4):885-95. [2]. Dutt V, et al. S-allyl cysteine inhibits TNFα-induced skeletal muscle wasting through suppressing proteolysis and expression of inflammatory molecules. Biochim Biophys Acta. 2018 Apr;1862(4):895-906. |
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Chemical & Physical Properties
| Density | 1.191 |
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| Boiling Point | 300 ºC |
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| Melting Point | 235-236 ºC |
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| Molecular Formula | C6H11NO2S |
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| Molecular Weight | 161.222 |
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| Flash Point | 135 ºC |
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| Exact Mass | 161.051056 |
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| PSA | 88.62000 |
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| LogP | 1.31 |
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| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
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| Index of Refraction | 1.543 |
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| Storage condition | 2-8°C |
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MSDS
S-Allyl-L-cysteine MSDS(Chinese) |
Safety Information
| Symbol | 
GHS07 |
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| Signal Word | Warning |
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| Hazard Statements | H317 |
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| Precautionary Statements | P280 |
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| Hazard Codes | F,C |
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| Risk Phrases | R11:Highly Flammable. R22:Harmful if swallowed. R34:Causes burns. R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . |
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| Safety Phrases | S16-S26-S36/37/39-S45 |
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| RIDADR | UN 2379 3/PG 2 |
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| WGK Germany | 3 |
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| RTECS | EO4460000 |
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| Packaging Group | II |
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| Hazard Class | 3.1 |
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| HS Code | 2930909090 |
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Precursor & DownStream
| Precursor 10 | Previous 1/3 Next |
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 CAS#:232953-12-7
N-Boc-S-allyl-L...
 CAS#:52-89-1
L-Cysteine hydr...
 CAS#:106-95-6
allyl bromide
 CAS#:52-90-4
L-cysteine
|
| DownStream 9 | Previous 1/3 Next |
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Customs
| HS Code | 2930909090 |
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| Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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2. Packaging of materials
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping & Delivery
Provide door to door service
Suitable for goods under 50kg
Delivery: 3-7 days
Cost: low cost
Provide airport to airport service
Suitable for goods over 50kg
Delivery: 3-14 days
Cost: high cost
Provide seaport to seaport service
Suitable for goods over 100kg
Delivery: 2-45 days
Cost: low cost
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