| Name | (-)-Securinine |
| Description | (-)-Securinine (Securinine) is plant-derived alkaloid and also a GABAA receptor antagonist. |
| In vitro | (-)-Securinine significantly inhibits HeLa cells growth with IC50 values of 7.02±0.52 μg/mL (32.3 μM). (-)-Securinine induces apoptosis in a dose-dependent manner in the tested cells, increases the percentage of ROS positive cells and depolarized cells as well as stimulates the activity of ERK1/2, caspase-9 and -3/7. (-)-Securinine also induces cell cycle arrest in S phase. Real-time PCR analysis shows high expression of tumor necrosis factor receptor superfamily (TNFRSF) genes in the cells stimulated with (-)-Securinine. |
| In vivo | In the tumor model, treatment with (-)-Securinine markedly inhibits tumor growth, suggesting its potential as an Acute Myeloid Leukemia (AML) treatment. Mice treated with (-)-Securinine (n=5 mice, bilateral tumors) show tumors that are, on average, over 75% smaller than those in vehicle-treated mice at the conclusion of the study. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 2 mg/mL (9.21 mM), Sonication is recommended.
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| Keywords | γ-Aminobutyric acid Receptor | Inhibitor | inhibit | Gamma-aminobutyric acid Receptor | GABAReceptor | GABAA | GABA Receptor | (-)-Securinine | ()Securinine |
| Inhibitors Related | Valproic acid sodium salt | p-Hydroxybenzaldehyde | Urethane | Baicalin | Penicillin G sodium salt | Valproic Acid | Methyl eugenol | (-)-α-Pinene | Nipecotic acid | Methionine | Dihydromyricetin | Isoflurane |
| Related Compound Libraries | Traditional Chinese Medicine Monomer Library | Pain-Related Compound Library | Anti-Neurodegenerative Disease Compound Library | Alkaloid Natural Product Library | Membrane Protein-targeted Compound Library | Drug Repurposing Compound Library | Natural Product Library | Inhibitor Library | Natural Product Library for HTS | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Drug Library |
United States
