| Name | δ-Tocotrienol |
| Description | δ-Tocotrienol (Delta-Tocotrienol) is a potential angiogenic inhibitor. δ-Tocotrienol is also a nontoxic activator of mir-34a which can inhibit nonsmall cell lung cancer cells (NSC-LC) cell proliferation, induce apoptosis and inhibit invasion, and thus offering a potential starting point for the design of novel anticancer agents. |
| In vitro | δ-Tocotrienol induced apoptosis and cell cycle arrest at G0/G1 and M phases in nasopharyngeal carcinoma cells. After CNE1 cells were treated with δ-Tocotrienol, 169 genes were up-regulated and 167 down-regulated. ERK1/2 was shown to play a vital role in cell cycle arrest by gene chips. δ-Tocotrienol induces cell cycle arrest in CNE1 cells via the p16/CDK4/cyclin D1 signaling pathway. CNE1 apoptosis was related to dysregulated expression of Bax-2 and Bcl-2. Furthermore, caspase-3, -8, -9 up-regulation was related to the apoptotic effect of δ-Tocotrienol[1]. |
| Storage | keep away from direct sunlight,keep away from moisture,High Volatility | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+90% Corn Oil : 3.3 mg/mL (8.32 mM), Sonication is recommended. DMSO : 100 mg/mL (252.14 mM), Sonication is recommended.
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| Keywords | Δ-Tocotrienol | δTocotrienol | δ Tocotrienol | VEGFR | PI3K | PDK | p53 | Inhibitor | inhibit | ERK | Bcl-2 | Akt |
| Inhibitors Related | Stavudine | Aceglutamide | Urea | Tamoxifen | Guanidine hydrochloride | Metronidazole | Ethyl linoleate | Formamide | Thymidine | Gluconate Calcium | Alginic acid | Sildenafil citrate |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Cytokine Inhibitor Library | HIF-1 Signaling Pathway Compound Library | Anti-Cancer Metabolism Compound Library | Anti-Obesity Compound Library | Anti-Ovarian Cancer Compound Library | Antioxidant Compound Library | Natural Product Library | Natural Product Library for HTS | Anti-Aging Compound Library | Human Endogenous Metabolite Compound Library Plus | Anti-Liver Cancer Compound Library |