Ziconotide is an analgesic agent and has been used to treat neuropathic and non-neuropathic pain. Ziconotide acts by binding to N-type calcium channels situated on the terminal part of primary afferent neurons of the nociceptive pathway therefore reducing synaptic transmission with potent antinociceptive effects[1].
Target
N-Type Ca2+ Channel
References
[1]. Brinzeu A, et al. Ziconotide for spinal cord injury-related pain. Eur J Pain. 2019 Oct;23(9):1688-1700.
The effect of spider toxin PhTx3-4, ω-conotoxins MVIIA and MVIIC on glutamate uptake and on capsaicin-induced glutamate release and [Ca2+]i in spinal cord synaptosomes.
Cell. Mol. Neurobiol. 31(2) , 277-83, (2011)
In spinal cord synaptosomes, the spider toxin PhTx3-4 inhibited capsaicin-stimulated release of glutamate in both calcium-dependent and -independent manners. In contrast, the conus toxins, ω-conotoxin...
Rationale for Prospective Assays of Intrathecal Mixtures Including Morphine, Ropivacaine and Ziconotide: Prevention of Adverse Events and Feasibility in Clinical Practice.
Pain Physician 18 , 349-57, (2015)
Use of intrathecal admixtures is widespread, but compounding these is sometimes challenging and may result in errors and complications causing super-potency or sub potency adverse events in patients o...
Prolonged delirium with psychotic features from omega conotoxin toxicity.
Pain Med. 14(3) , 447-8, (2013)
Synonyms
Ziconotide
ω-conotoxin MVIIA
SNX-111,Ziconotide
o-Conotoxin MVIIA
SNX-111 Ziconotide
snx111
Ziconotideacetate
Prialt
SNX-111
CKGKGAKCSRLMYDCCTGSCRSGKC-NH2
2. Packaging of materials
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
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