| Name | 0990CL |
| Description | 0990CL is an effective heterotrimer Gαi subunit specific inhibitor, which can interact with purified Go± in GDP-bound state, and can block α2AR mediated cAMP regulation. In the cell model, low concentration of 0990CL could partially restore cAMP level, and high concentration of 0990CL (10μM) began to have negative effects on cell viability. |
| In vitro | 0990CL (at a concentration of 30 μM with a 30-minute pre-treatment) exhibits preferential binding to Gαi1 compared to Gαq. It displays selectivity towards Gαi and Gαq, resulting in a maximum reduction of endpoint fluorescence by 38±8% and 10%, respectively. Treatment with 0990CL (100 nM to 1 μM , 24 h) restores α2AR/Gαi-mediated cAMP levels induced by Fsk and UK14304 in HEK293 GloSensor cells. At a dosage of 100 nM, it reinstates 31% of the reduced cAMP levels[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (5.82 mM), Sonication is recommended.
DMSO : 45 mg/mL (131.03 mM), Sonication is recommended.
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| Keywords | heterotrimeric G-protein complex | Gαi subunit | cAMP | 0990CL |
| Inhibitors Related | Trifluoperazine dihydrochloride | Mirtazapine | Octopamine hydrochloride | Gemfibrozil | Buflomedil hydrochloride | Dexmedetomidine hydrochloride | Isoprenaline hydrochloride | D-Mannitol | Mianserin hydrochloride | Trazodone hydrochloride | Atenolol | Doxepin hydrochloride |
| Related Compound Libraries | Bioactive Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Multi-Target Compound Library | Inhibitor Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Compound Library |
United States
