1,12-Diaminododecane NEW

• DATA ITEMS CITED :

• 8

• MOLECULAR FORMULA :

• C12-H28-N2

• MOLECULAR WEIGHT :

• 200.42

• WISWESSER LINE NOTATION :

• Z12Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

• TYPE OF TEST :

• Standard Draize test

• ROUTE OF EXPOSURE :

• Administration into the eye

• SPECIES OBSERVED :

• Rodent - rabbit

• REFERENCE :

• ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,92,1990 ** ACUTE TOXICITY DATA **

• TYPE OF TEST :

• LDLo - Lowest published lethal dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 670 mg/kg

• TOXIC EFFECTS :

• Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain

• REFERENCE :

• ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,92,1990

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Unreported

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 1088 mg/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• REFERENCE :

• GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 43(5),18,1978

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Unreported

• SPECIES OBSERVED :

• Rodent - rabbit

• DOSE/DURATION :

• 330 mg/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• REFERENCE :

• GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 43(5),18,1978

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Unreported

• SPECIES OBSERVED :

• Rodent - guinea pig

• DOSE/DURATION :

• 440 mg/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• REFERENCE :

• GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 43(5),18,1978 ** OTHER MULTIPLE DOSE TOXICITY DATA **

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rabbit

• DOSE/DURATION :

• 54600 ug/kg/26W-I

• TOXIC EFFECTS :

• Endocrine - changes in thymus weight Blood - change in clotting factors Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

• REFERENCE :

• GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 43(5),18,1978