Racecadotril Cas 81110-73-8
Specification
Items | Specification | Result |
Appearance | White or off-white crystalline powder | White crystalline powder |
Assay | 98%-102% | 99.7% |
Loss on drying | ≤0.5% | 0.06% |
Sulphated ash | ≤0.1% | 0.02% |
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Based on the provided reference materials, there is no information available regarding Racecadotril. The documents exclusively discuss a different medication called Lisinopril.
To ensure you have accurate information, I have detailed the profile of Lisinopril below based on the search results. If you intended to ask about Racecadotril, I recommend consulting a medical professional or specific pharmacological databases, as it is not covered in the provided text.
What is Lisinopril?
Lisinopril is a long-acting oral Angiotensin-Converting Enzyme (ACE) inhibitor. It is widely used in cardiovascular medicine to manage blood pressure and heart conditions. It works by inhibiting the angiotensin-converting enzyme, which reduces the production of Angiotensin II (a substance that narrows blood vessels). This leads to relaxed blood vessels and lower blood pressure.
Key Selling Points & Clinical Benefits
Based on the reference materials, the primary advantages and uses of Lisinopril include:
1. Effective Blood Pressure Control
Mechanism: It lowers blood pressure by reducing peripheral vascular resistance without increasing heart rate.
Efficacy: It is effective for primary and renal hypertension. Studies suggest it may have a more ideal antihypertensive effect compared to Captopril and better 24-hour blood pressure control compared to Enalapril.
Duration: It has a long duration of action (up to 24 hours or more), allowing for once-daily dosing, which improves patient compliance.
2. Heart Failure Management
Symptom Relief: It is used as an adjunctive treatment for congestive heart failure (usually with diuretics and digoxin). It reduces symptoms like shortness of breath and fatigue.
Survival & Function: It improves exercise tolerance, left ventricular ejection fraction, and quality of life. It helps prevent the progression of heart failure and reduces mortality rates.
3. Protection After Heart Attacks (Acute Myocardial Infarction)
Early Intervention: When used within 24 hours of a heart attack in hemodynamically stable patients, it improves survival rates.
Remodeling: It prevents left ventricular dysfunction and adverse remodeling (enlargement) of the heart after an infarction.
4. Kidney Protection (Renoprotection)
Diabetic Nephropathy: It is highly effective in reducing proteinuria (protein in the urine) in patients with diabetes.
Mechanism: By lowering intraglomerular pressure, it helps slow the progression of kidney disease in both diabetic and non-diabetic patients.
Important Safety Information
While Lisinopril is generally well-tolerated, there are specific risks and contraindications you must be aware of:
Category Details
Common Side Effects Dry cough (a characteristic side effect of ACE inhibitors), dizziness, headache, fatigue, and nausea.
Contraindications Pregnancy (especially 2nd and 3rd trimesters due to fetal toxicity), history of angioedema (swelling of face/lips/throat), and bilateral renal artery stenosis.
Key Interactions Potassium supplements or potassium-sparing diuretics (risk of hyperkalemia/high potassium). NSAIDs (like ibuprofen/indomethacin) may reduce its effectiveness.
Precautions Patients should be monitored for low blood pressure (hypotension) when starting treatment, especially if dehydrated or on diuretics.
Note: Always consult a healthcare provider before starting or changing any medication regimen.
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Contact information
Spring Zhang
Email: export@fortunachem.com
Skype: Fortunachem201304
QQ:3169620873
Tel: +86-27-59207892
Website: www.fortunachem.com
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