2-chloro-6-nitroquinoline

2-Chloro-6-nitroquinoline (CNDQ) is a synthetic compound that is used as an analog of serotonin. This compound has been shown to be a potent and selective serotonin reuptake inhibitor in vivo, with affinities for the serotonin transporter that are more than 100 times greater than other monoamine transporters. CNDQ has also been observed to inhibit the uptake of dopamine and norepinephrine, which may account for its antidepressant activity. The alkyl groups on this molecule enhance its binding affinity for amine receptors.

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