2-Ethoxy-4,6-Dichloropyrimidine CAS 40758-65-4 | Leading Supplier of Highly Active Chlorinated Pyrimidine Intermediates
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Product Basics
Chemical Name: 2-Ethoxy-4,6-dichloropyrimidine
CAS No.: 40758-65-4 (Title-level keyword emphasis)
Molecular Formula: C₆H₆Cl₂N₂O
Molecular Weight: 205.03 g/mol
Appearance: White to light yellow crystalline powder
Purity: ≥98.5% (HPLC, pharmaceutical intermediate grade)
Key Physicochemical Properties (Structured Data Optimization)
| Attribute | Value |
|---|
| Melting Point | 90-93℃ (dynamic DSC measurement) |
| Boiling Point (0.5 mmHg) | 210-213℃ |
| Density (25℃) | 1.45 g/cm³ |
| Solubility | Freely soluble in acetone, DCM; slightly soluble in EtOH; insoluble in water |
| Flash Point (closed cup) | >150℃ |
| Storage Conditions | Airtight, light-protected, stored at RT in a dry place |
Integrated Industry Chain
▶ Upstream Material Assurance
Core Intermediates: 2-Ethoxypyrimidine-4,6-diol, phosphoryl chloride (POCl₃)
Process Optimization: Stepwise chlorination technology (selectivity >97%, byproducts <0.3%)
▶ Downstream Application Expansion
Agrochemical Fungicides: Strobilurin derivatives (e.g., azoxystrobin) resistance management
Antiviral Drugs: HCV NS5B polymerase inhibitor scaffold modification
Optoelectronic Materials: Organic semiconductor hole-transport layer fabrication
Molecular Probes: Targeted protein covalent inhibitor design
Industry Solutions & Technical Advantages
| Application Field | Typical Scenario | Technical Strengths |
|---|
| Agrochemicals | Targeted development for resistant strains of broad-spectrum fungicides | Nucleophilic substitution reactivity of Cl >96% (HPLC verified) |
| Anti-infectives | COVID-19 main protease inhibitor synthesis | Ethoxy group stability (pH 5-9 tolerance) |
| OLED Materials | Electron transport layer dopant precursor | Purity ≥99.9% (gradient sublimation process) |
| Chemical Biology | Covalent inhibitor warhead optimization | Chlorine substituent reaction efficiency >93% |
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Long-Tail Keywords:
"Custom synthesis of azoxystrobin intermediates"
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Compliance Statements
✅ EINECS Status: Not listed (verified via ECHA database)
✅ REACH Progress: Under consortium registration (SIEF member ID: CHEM-2024-XXXXX)
✅ EU Export: PPORD exemption support (R&D use, annual export <1 ton)
✅ Analytical Reports: Full documentation provided (HPLC, ¹H NMR, elemental analysis)
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