| Name | 2-Hydroxybenzylamine |
| Description | 2-Hydroxybenzylamine, a potent small molecule scavenger of IsoLGs, sequesters the reactive species as inert adducts. 2-Hydroxybenzylamine may be used to decrease early recurrence of atrial fibrillation and other atrial arrhythmias following atrial fibrillation ablation by decreasing IsoLG adducts with native biomolecules. |
| In vivo | Compared to hypercholesterolemic Ldlr-/- mice treated with vehicle or 4-Hydroxybenzylamine, a nonreactive analogue, 2-Hydroxybenzylamine decreases atherosclerosis by 60% in en face aortas, without changing plasma cholesterol. Ldlr-/- mice treated with 2-Hydroxybenzylamine have reduced MDA-LDL and MDA-HDL levels, and their HDL display increased capacity to reduce macrophage cholesterol. Importantly, 2-Hydroxybenzylamine reduces the MDA- and IsoLG-lysyl content in atherosclerotic aortas versus 4-Hydroxybenzylamine. Furthermore, 2-Hydroxybenzylamine reduces inflammation and plaque apoptotic cells and promotes efferocytosis and features of stable plaques. Dicarbonyl scavenging with 2-Hydroxybenzylamine has multiple atheroprotective effects in a murine FH model[2]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween-80+45% Saline : 2 mg/mL (16.24 mM), Sonication is recommended.
DMSO : 45 mg/mL (365.41 mM), Sonication is recommended.
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| Keywords | scavenger | Reactive Oxygen Species | radical | oxidative stress | o-Hydroxybenzylamine | IsoLGs | Inhibitor | inhibit | inflammation | FH model | atrial fibrillation | atherosclerosis | arrhythmias | antioxidant | 2-Hydroxybenzylamine | 2Hydroxybenzylamine | 2-HOBA | 2 Hydroxybenzylamine |
| Inhibitors Related | Ethoxyquin | Kaolin | Allopurinol | Cysteamine hydrochloride | Ethyl linoleate | Magnesium acetate tetrahydrate | Inosine | L-Cystine | Copper Sulfate Pentahydrate | Dimethyl itaconate | L-Ascorbic acid sodium salt | Dimethyl phthalate |
| Related Compound Libraries | NF-κB Signaling Compound Library | Bioactive Compound Library | Selected Plant-Sourced Compound Library | Antioxidant Compound Library | Drug Repurposing Compound Library | Anti-Cardiovascular Disease Compound Library | RO5 Drug-like Natural Product Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Clinical Compound Library | Bioactive Compounds Library Max |
United States
