| Name | 2-Hydroxysaclofen |
| Description | 2-Hydroxysaclofen is a potent γ-amino-butyric-acid-B receptor antagonist that effectively abolishes nicotine-induced hypolocomotor effects, enhances antinociceptive responses, and stimulates luteinizing hormone secretion in female rats, making it a valuable pharmacological probe for investigating GABAB receptor–mediated neuroendocrine regulation and behavioral pharmacology. |
| In vivo | In male Swiss Webster mice, intraperitoneal (IP) administration of 2-Hydroxysaclofen (0.25-1 mg/kg) modulates the acute effects of nicotine. At a dose of 1 mg/kg, it abolishes nicotine-induced hypolocomotion while enhancing its antinociceptive effects. In male Wistar rats, IP administration (0.3-3 mg/kg) antagonizes the ability of Baclofen to alter the discriminative stimulus effects of d-amphetamine. Furthermore, in estrogen-primed ovariectomized female rats, intracerebroventricular (ICV) injection (50-100 ug/mL) leads to an elevation in serum Luteinizing Hormone (LH) concentrations, with peak levels observed 10 minutes post-injection [1][2][3]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 1M NaOH : 25 mg/mL (94.09 mM), Sonication is recommended. H2O : 40 mg/mL (150.54 mM), when pH is adjusted to 11 with 1 M NaOH. Sonication is recommmended. 1eq. NaOH : 100 mM, Sonication is recommended.
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| Keywords | 2-Hydroxysaclofen | 2Hydroxysaclofen | 2 Hydroxysaclofen |
| Inhibitors Related | Valproic acid sodium salt | p-Hydroxybenzaldehyde | Urethane | Baicalin | Penicillin G sodium salt | Valproic Acid | Methyl eugenol | (-)-α-Pinene | Nipecotic acid | Methionine | Dihydromyricetin | Isoflurane |
| Related Compound Libraries | Bioactive Compound Library | Bioactive Compounds Library Max |